Fungal Morphogenesis: Some Like It Hot

Fungal Morphogenesis: Some Like It Hot

The ability to reversibly convert between budding yeast-like and filamentous hyphal forms is important for the virulence of Candida albicans. A new study now provides insight into the relationship between environmental temperature and the signalling mechanisms that regulate morphogenesis in this fungal pathogen.

Thermosensation: Some like it hot

The ability of organisms to respond to fluctuating temperatures is ubiquitous but poorly understood. Recent studies of nematodes reveal specific sensory neurons and interneurons that mediate thermotaxis.

Some don't like it hot.

Fungal Morphogenesis: In Hot Pursuit

Temperature affects diverse biological processes. In fungi such as the pathogen Candida albicans, temperature governs a morphogenetic switch between yeast and hyphal growth. A new report connects the thermosensor Hsp90 to a CDK-cyclin-transcription factor module that controls morphogenesis.

Some like it hot: lymphoma radioimmunotherapy.

Radioimmunotherapy (RIT or RAIT) dates back more than 2 decades and has evolved to encompass a variety of tumorseeking antibodies in various forms, with different radionuclides, different delivery methods, for different clinical indications (usually advanced disease).1 Although selective antibody targeting has been demonstrated, the radiation doses delivered have been insufficient to markedly i...